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Model for the mechanism of the Hop2-Mnd1-DMC1-ssDNA ensemble. Our model posits that Hop2–Mnd1 stabilizes the DMC1 presynaptic filament by its ssDNA binding activity within the C-terminus of Hop2 and helps capture duplex DNA by its dsDNA binding function located in the N-termini of Hop2 and Mnd1, thus increasing the efficiency at which the duplex could be engaged and sampled for DNA homology by the DMC1 presynaptic filament.
