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. 2013 Oct 23;42(2):979–998. doi: 10.1093/nar/gkt942

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 12. — AmpR-mediated regulation of virulence and physiological processes in P. aeruginosa. AmpR affects expression of QS genes by directly binding to P_lasR and modulating lasR expression. AmpR also positively regulates the PQS by modulating levels of the antisense RNA asPrrF1, thus also affecting iron uptake. By regulating expression of the stationary-phase sigma factor RpoS (21), oxyR and the small RNA rgRgsA, AmpR positively regulates the oxidative stress response. The genes encoding the Hsp70 heat-shock response system are also positively regulated by AmpR. This and previous findings (21) demonstrate that AmpR is a major regulator of virulence and physiological processes in P. aeruginosa.