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. 2013 Oct 23;42(2):1303–1310. doi: 10.1093/nar/gkt949

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Evolution of upper and lower bulge in the typical DAse ribozymes. Nucleotide conservation obtained by NGS of DAse selection pools. To analyze the evolution of these bulges, several pools were analyzed for the nucleotide conservation in the upper and lower bulge (shown as frequency plots). The secondary structure is showing the preferred nucleotide composition of typical DAse ribozymes, pie-charts show the fractions of sequence reads that have a typical DAse fold identified by RNABOB and the sequences shown below the frequency plot show random (black) and (semi-)conserved (gray) nucleotides, as used in the RNABOB descriptor (see Supplementary Text S4).