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Cells defective in FANCJ show increased 1H6 fluorescence. (a) TMS induces elevated numbers of 1H6 foci in FANCJ DT40 chicken cells. FANCJ DT40 cells or cells expressing human FANCJ-WT were either exposed to 5 μM TMS for 2 h or left unexposed, fixed and stained with 1H6 (red) and DAPI (blue). (b) Quantification of the change in 1H6 foci with and without TMS treatment. The graph illustrates the mean ± s.e.m of the G4 foci in each cell. More than 100 cells were scored for each sample.
