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HIV-1 RT–PPT/DNA during plus-strand primer selection. Based on the structure reported by Sarafianos et al. (10), the schematic reflects the projected positioning of RT for cleavage at the PPT–U3 junction (open circle), as well as the nucleic acid distortion centered around positions –12/–13. Anticipated locations of DNA polymerase and RNase H active sites, the RNase H primer grip and all residues projected to contact nucleic acid are indicated. PPT nucleotides are indicated in bold.
