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Effects of continuous kisspeptin-10 on LH pulse frequency, mean LH levels and AUC: (a) mean (±SEM) frequency of gonadotropin pulses, (b) mean (±SEM) LH levels, and (c) mean (±SEM) LH AUC in 4 patients with hypogonadotropic hypogonadism caused by NKB (TAC3) or NK3R (TACR3) mutations receiving vehicle (white column) and kisspeptin (black column). * p < 0.05 paired t test.
