Table 1.
Mean (±SD) serum LH, FSH, inhibin B, testosterone and estradiol concentrations in patients with congenital hypogonado-tropic hypogonadism caused by NKB (patients 1 and 2) or NK3R (patients 2 and 3) biallelic mutations receiving vehicle (saline) and then kisspeptin-10 (Kp10) infusion
| Patient 1 (male) |
Patient 2 (male) |
Patient 3 (female) |
Patient 4 (male) |
Normal range1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| saline | Kp10 | saline | Kp10 | saline | Kp10 | saline | Kp10 | ||
| LH, IU/l | 0.20±0.1 | 0.40 ± 0.2*** | 0.62 ± 0.41 | 1.21 ± 0.60*** | 0.22 ± 0.06 | 1.25 ± 0.56*** | 0.42 ± 0.10 | 1.12 ± 0.43*** | M: 2.6–6.5; F: 4–7.0 |
| FSH, IU/l | 2.9 ± 0.2 | 3.4± 0.5*** | 4.4 ± 0.6 | 7.1 ± 1.1 *** | 2.1 ± 0.1 | 4.2 ± 0.9*** | 3.0 ± 0.2 | 5.4 ± 0.7*** | M: 2.7–7.4; F: 4–7.4 |
| Inhibin B | |||||||||
| pg/ml | 15.9 ± 3.2 | 27.4 ± 4.6* | 10.4 ± 1.6 | 19.1 ± 3.1 * | 8.15 ± 2.9 | 26.2 ± 4.7** | 66 ± 7.4 | 112 ± 13.7** | M: 80–330; F: 60–125 |
| Testosterone | |||||||||
| ng/ml | 0.13±0.1 | 0.4 ± 0.2* | 0.12 ± 0.08 | 0.6 ± 0.14* | ND | ND | 0.42 ± 0.10 | 1.12 ± 0.43* | M: 3.5–±.5 |
| Estradiol | |||||||||
| pg/ml | ND | ND | ND | ND | 6.4 ± 1.9 | 18.2 ± 3.1** | ND | ND | F: 25–90 |
During each treatment, 12 random measurements of inhibin B, testosterone and estradiol were performed. ND = Not determined.
*
p < 0.05;
**
p < 0.01;
***
p < 0.0001 (paired t test).
1
Normal hormonal range in postpubertal males (M) and females (F).