Table 4.
Significant SNPs and SNP-SNP pairs
| SNP or SNP-SNP interaction | Phenotype | P values (uncorrected) a | Minor allele/major allele b | MAF (HapMap CEPH) c |
Frequency of minor allele |
χ
2
|
|
|---|---|---|---|---|---|---|---|
| Cases | Controls | ||||||
| rs7180158 |
AS |
3.58E-04 |
A/G |
A = 0.24 |
0.1624 |
0.08272 |
12.74 |
| rs7165604 |
AS |
4.51E-04 |
C/T |
C = 0.17 |
0.1174 |
0.05145 |
12.31 |
| rs12593579 |
AS |
6.68E-04 |
C/A |
C = 0.21 |
0.194 |
0.1093 |
11.58 |
| rs11636966 |
EQ |
5.94E-04 |
T/C |
T = 0.22 |
NA |
NA |
NA |
| rs9806546 |
EQ |
1.47E-03 |
A/G |
A = 0.40 |
NA |
NA |
NA |
| rs12438141-rs1035751 |
EFT |
7.59E-06 |
C/T - A/G |
T = 0.13, G = 0.06 |
NA |
NA |
NA |
| rs12438141-rs7179514 |
EFT |
5.21E-06 |
C/T - C/G |
T = 0.13, G = 0.31 |
NA |
NA |
NA |
| rs7174437-rs1863455 | MRT | 1.58E-05 | C/T - C/T | C = 0.12, C = 0.08 | NA | NA | NA |
Abbreviations: AQ, Autism Spectrum Quotient; AS, Asperger syndrome; EFT, Embedded Figures Test; EQ, Empathy Quotient; MRT, Mental Rotation Test; NA, not applicable; SNP, single nucleotide polymorphism.
aCorrected P-value threshold is 3.6 × 10-05.
bAlleles for SNP-SNP pairs have been provided in the order they are written.
cMAF for SNP-SNP pairs have been provided in the order they are written.