FIG. 3.

Structural model of the Nef C-terminal loop interaction with the AP2 complex. (A) The Nef loop is shown in yellow and the AP2 surface in gray. The dileucine motif pocket is colored orange, the new L₁₇₀ binding pocket is shown in green, and the basic patch involved in Nef binding to AP2 is shown in blue. (B) The electrostatics properties of the same region are shown for AP2. The surface of AP2 is colored based on the electrostatics potential computed from the protein structure. Blue indicates regions of positive electrostatic potential and red regions indicate regions of negative electrostatic potential. White indicates regions that are relatively neutral. Color images available online at www.liebertpub.com/aid