Fig. 6.

CSE inhibition in the carotid body controls hypertension in SH rats. (A–C) Average (mean ± SEM) data of systolic (SBP), diastolic (DBP), and mean (MBP) blood pressures in SH rats over 5 wk. Arterial blood pressures were measured in 5-wk-old SH rats every week for 5 wk. Rats were treated every alternate day with vehicle (saline) or a CSE inhibitor (l-PAG; 30 mg/kg, i.p.) either alone or after carotid body transection. n = 6–7 rats in each group. *P < 0.05; **P < 0.01; n.s. P > 0.05 (i.e., not significant).