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. 2013 Dec 9;111(3):E374–E383. doi: 10.1073/pnas.1306798111

Fig. 5.

Fig. 5.

TGF-β activation of PLD1 and PIP5K1α is required for βENaC internalization. (A) The impact of PLD1 gene ablation by siRNA [or scrambled (scr) siRNA] on βENaC internalization by A549 cells in response to TGF-β (10 ng/mL) assessed by biotin pull-down. Effect of PIP5K1A gene ablation by siRNA on (B) βENaC internalization and (C) [3H]phosphatidic acid (PA) production by A549 cells in response to TGF-β. Data represent mean ± SD *P < 0.05 (n = 3, per group). UT; untransfected; EV, empty vector-transfected, Lam, Lamin A/C.