Table I.

Selectivity of PKCθ Functions in vivo

in vivo immune responses	Role of PKCθ	Immune cells implicated in response	References
Effector function/memory responses/ viral clearance upon LCMV infection	Dispensable	CTL, Th1	Berg-Brown et al., 2004
Neutralizing antibodies against VSV infection	Dispensable	B cells, Tfh help	Berg-Brown et al., 2004
Murine herpes virus-68 clearance, expansion of virus-specific CD8+ T cells	Dispensable	CTL	Giannoni et al., 2005
Recall responses to vaccinia virus infection	Dispensable	CTL	Marsland et al., 2005
Murine CMV clearance, expansion of virus-specific CD8+ T cells	Dispensable	CTL	Valenzuela et al., 2009
Effector CTL response to Listeria Monocytogenes (LM) infection1	Dispensable	CTL	Valenzuela et al., 2009
LM clearance, effector cell expansion2	Required	CTL, Th1	Sakowicz-Burkiewicz et al., 2008
Effector response against T. gondii infection, pathogen clearance	Required	Th1, CTL, Th2, B cells	Nishanth et al., 2010
Plasmodium berghei ANKA-induced Inflammatory cerebral malaria	Moderately required	Th1, CTL?	Ohayon et al., 2010
Leishmenia major clearance, effector response against infection	Dispensable (B6)	Th1	Marsland et al., 2004
	Required (Balb/C)	Th2
Immunity to M-MuLV-induced leukemia	Required	CTL, Th1	Garaude et al., 2008
Rejection of engrafted MHC class I-negative tumors	Required	NK	Aguilo et al., 2009
Lung inflammation induced by ovalbumin administration	Dispensable	Th13	Salek-Ardakani et al., 2004; Marsland et al. 2004
	Required	Th24
IgE, eosinophilia response to N. Brasiliensis infection	Required	Th2	Marsland et al., 2004
GvL response	Dispensable	Th1, CTL?	Valenzuela et al., 2009
Systemic GvHD	Required	Th1, CTL	Valenzuela et al., 2009
Local (footpad) host vs. graft response	Required	Th1, CTL	Anderson et al., 2006
Early (1–3 hr) cytokine response to anti-CD3 injection	Required	NKT?	Anderson et al., 2006
Cardiac allograft rejection	Mildly required; cooperates with PKCα	Th1, CTL	Gruber et al., 2009
	Required		Manicassamy et al., 2008
Coxsackie B3-induced autoimmune myocarditis	Dispensable	Th1	Marsland et al., 2007
α-myosin/CFA-induced experimental autoimmune myocarditis	Required	Th17	Marsland et al., 2007
Autoimmune colitis, EAE	Required	Th17, Th1	Anderson et al., 2006; Salek-Ardakani et al., 2005;Tan et al., 2006
Methylated BSA-induced arthritis	Required	Th1, Th2, B cells	Healy et al., 2006
Concanavalin A-induced autoimmune hepatitis	Required	NKT	Fang et al., 2012

¹2×10³ CFU LM-Ova

²5×10⁴ CFU LM-Ova

³Ova/CFA immunization s.c.

⁴Ova/alum immunization i.p.