Skip to main content
. 2013 Sep 30;592(Pt 1):215–227. doi: 10.1113/jphysiol.2013.263814

Figure 2. Calcineurin inhibition increases NMDAR activity in the spinal dorsal horn.

Figure 2

A and B, representative current traces (averaged responses from 6 EPSCs, A) and group data (B) show that FK506 treatment increased the ratio of NMDAR-EPSCs to AMPAR-EPSCs of lamina II neurons. The spinal cord slices were obtained from rats treated with FK506 or vehicle for 7 days. The holding potential was indicated on the left in A. C, original traces and summary data show NMDAR currents elicited by puff application of NMDA to lamina II neurons in vehicle-treated (n= 10 neurons) and FK506-treated (n= 11 neurons) rats. D, representative traces and group data show AMPAR currents elicited by puff application of AMPA to lamina II neurons in vehicle-treated (n= 18 neurons) and FK506-treated (n= 16 neurons) rats. *P < 0.05 compared with the value in the vehicle-treated group.