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. 2013 Sep 30;592(Pt 1):215–227. doi: 10.1113/jphysiol.2013.263814

Figure 6. Contribution of GluN2A and GluN2B to increased presynaptic NMDAR activity in the spinal cord by FK506 treatment.

Figure 6

A, original traces and cumulative plots show that bath application of 0.6 μm Ro25-6981 alone and 5 μm AP5 plus 0.6 μm Ro25-6981 reduced the frequency, but not the amplitude, of mEPSCs in one lamina II neuron recorded from an FK506-treated rat. B, mean changes in the frequency and amplitude of mEPSCs in lamina II neurons during baseline control, bath application of 0.6 μm Ro25-6981, bath application of 5 μm AP5 plus 0.6 μm Ro25-6981, and washout in FK506-treated (n= 9 neurons) rats. mEPSCs were recorded in lamina II neurons using internal pipette solution containing 1 mm MK-801 to block postsynaptic NMDARs. *P < 0.05 compared with the baseline control. #P < 0.05 compared with Ro25-6981 alone.