Figure 8. Systemic administration of memantine alleviates mechanical hypersensitivity of rats chronically treated with FK506.

A and B, time course of the effect of a single injection of memantine (1–10 mg kg⁻¹, i.p.) on the paw withdrawal threshold tested with von Frey filaments (A) and a noxious pressure stimulus (B) in rats treated with FK506 (1.5 mg kg⁻¹ day⁻¹ for 7 days). n= 7–8 rats per group. *P < 0.05 compared with the respective baseline value (time 0).