Figure 5. Absence of spontaneous excitatory postsynaptic currents (sEPSCs) in R424H mutant-expressing PCs.

Aa, Ba and C, representative current traces recorded from PCs expressing GFP alone (Aa), WT subunits (Ba) or R424H mutant subunits (C). The sEPSCs appear as downward deflections in Aa and Ba. The PCs were held at −80 mV in the presence of picrotoxin. Ab and Bb, averaged sEPSCs from the same cell as in Aa and Ba, with superimposed single exponential fit. The decay time constant is indicated beside each trace.