Table 2.

Summary of spontaneous excitatory postsynaptic current (sEPSC) properties in Purkinje cells

	Percentage of cells showing sEPSCsa	Amplitude (pA)b	Frequency (Hz)b	10–90% Rise time (ms)b	Decay time constant (ms)c
GFP alone	100%	33.7 ± 9.3	0.62 ± 0.35	0.18 ± 0.04	0.84 ± 0.27
(n= 15; 1502 events)	(15 of 15 cells)	(n= 15)	(n= 15)	(n= 15)	(n= 15)
WT mKv3.3	100%	34.0 ± 12.0	0.73 ± 0.35	0.19 ± 0.03	0.87 ± 0.19
(n= 10; 1041 events)	(10 of 10 cells)	(n= 10)	(n= 10)	(n= 10)	(n= 10)
R424H mutant	23%	23.1 ± 4.2	0.15 ± 0.10	0.20 ± 0.02	1.14 ± 0.21
(n= 3; 103 events)	(3 of 13 cells)**††	(n= 3)	(n= 3)*†	(n= 3)	(n= 3)

All measurements were performed at a holding potential of −80 mV. The statistical analyses indicated by superscript letters a and b were conducted using Student’s unpaired t test and Fisher’s exact probability test, respectively. ^cThe sEPSC decay phases were fitted with a single exponential function. ^*P < 0.05, ^**P < 0.001 between GFP alone and R424H mutant. †P < 0.05, ††P < 0.001 between WT mKv3.3 and R424H mutant.