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. 2014 Jan 27;9(1):e81699. doi: 10.1371/journal.pone.0081699

Table 4. The 35 studies reporting a positive (white) or negative (grey) statistical significance of a prognostic threshold of ejection fraction.

Author Publication Year Number of patients Age (years) Males (%) Primary outcome Max duration of follow-up (months) Number of events Mean±SD EF (%) Tested threshold (%) Tested threshold prognostically significant?
Itoh 1992 298 63±11 57 overall mortality 40 167 35±nr 40 yes
Mehta 1992 112 66±8 74 cardiac mortality 78 31 33±nr 30 yes
Rihal 1994 102 61±14 63 overall mortality 36 35 23±8 25 yes
Omland 1995 145 61±10 80 overall mortality 44 36 51±10 49,1 yes
Andreas 1996 36 54±12 90 overall mortality 53 16 20±8 20 yes
Giannuzzi 1996 508 59±9 88 overall mortality+hospitalization 58 148 26±5 25 yes
Szabo 1997 159 61±nr 85 overall mortality 69 30 26.6±9 27 yes
Anker 1997 171 60±11 90 overall mortality 18 49 30±15 25 yes
Wijbenga 1998 64 59±10 86 overall mortality+transplantation 30 64 31±8 30 yes
Niebauer 1999 99 58±2 90 overall mortality 36 73 13,3±nr 10 no
Metra 1999 219 55±10 93 overall mortality+urgent transplantation 144 38 22±7 20 yes
Isnard 2000 264 51±12 80 cardiac mortality+urgent transplantation 206 83 27±10 27 yes
Ghio 2000 140 52±11 75 cardiac mortality+urgent transplantation 38 52 22±2 20 yes
McDonagh 2001 1640 50,4±nr 48 overall mortality 48 80 47±nr 40 no
Neglia 2002 64 52±12 87 cardiac mortality 82 24 34±10 35 no
Corrà 2002 600 58±7 88 cardiac mortality+urgent transplantation 102 87 26±4 25 yes
Szachniewicz 2003 176 63±nr 86 overall mortality 18 32 42±nr 35 yes
Gardner 2003 142 50±10 82 cardiac mortality+urgent transplantation 55 24 14.9±7 13 no
Martinez-Selles 2003 1065 75±nr 49 overall mortality 51 507 35±7 30 no
Shiba 2004 684 67±13 66 overall mortality 33 175 49±15 25 no
Guazzi 2005 128 60±9 79 cardiac mortality 51 24 34±10 35 yes
Kistorp 2005 195 69±nr 71 overall mortality 30 46 30±8 25 yes
Junger 2005 209 54±10 86 overall mortality 35 45 22±10 20 yes
Peterson 2005 61 53±11 86 overall mortality+urgent transplantation 139 32 26±9 27 no
Bloomfield 2006 549 56±10 71 cardiac mortality 24 51 25±6 31 no
Rossi 2007 273 62±nr 87 overall mortality 45 44 31±3 30 yes
Arslan 2007 43 62±10 86 overall mortality 24 16 35±6 30 yes
Guazzi 2007 288 55±13 62 overall mortality 33 62 33±13 28 yes
vonHaeling 2007 525 61±12 94 overall mortality 28 171 28±4 20 yes
Nishio 2007 145 67±1.8 70 cardiac mortality+hospitalization 33 28 31±nr 30 no
Dini 2007 356 70±6 22 cardiac death 34 54 31±3 25 no
Whalley 2008 228 70±3 66 cardiac mortality+hospitalization 18 26 57±12 45 no
Dini 2008 142 71±11 78 overall mortality 50 85 28±7 25 no
Parissis 2009 300 65±11 83 cardiac mortality+hospitalization 12 92 28±4 25 no
Smilde 2009 90 60±8 85 overall mortality 156 47 29±9 30 yes

EF = left ventricular ejection fraction; nr = not reported.