Table 4. The 35 studies reporting a positive (white) or negative (grey) statistical significance of a prognostic threshold of ejection fraction.
Author | Publication Year | Number of patients | Age (years) | Males (%) | Primary outcome | Max duration of follow-up (months) | Number of events | Mean±SD EF (%) | Tested threshold (%) | Tested threshold prognostically significant? |
Itoh | 1992 | 298 | 63±11 | 57 | overall mortality | 40 | 167 | 35±nr | 40 | yes |
Mehta | 1992 | 112 | 66±8 | 74 | cardiac mortality | 78 | 31 | 33±nr | 30 | yes |
Rihal | 1994 | 102 | 61±14 | 63 | overall mortality | 36 | 35 | 23±8 | 25 | yes |
Omland | 1995 | 145 | 61±10 | 80 | overall mortality | 44 | 36 | 51±10 | 49,1 | yes |
Andreas | 1996 | 36 | 54±12 | 90 | overall mortality | 53 | 16 | 20±8 | 20 | yes |
Giannuzzi | 1996 | 508 | 59±9 | 88 | overall mortality+hospitalization | 58 | 148 | 26±5 | 25 | yes |
Szabo | 1997 | 159 | 61±nr | 85 | overall mortality | 69 | 30 | 26.6±9 | 27 | yes |
Anker | 1997 | 171 | 60±11 | 90 | overall mortality | 18 | 49 | 30±15 | 25 | yes |
Wijbenga | 1998 | 64 | 59±10 | 86 | overall mortality+transplantation | 30 | 64 | 31±8 | 30 | yes |
Niebauer | 1999 | 99 | 58±2 | 90 | overall mortality | 36 | 73 | 13,3±nr | 10 | no |
Metra | 1999 | 219 | 55±10 | 93 | overall mortality+urgent transplantation | 144 | 38 | 22±7 | 20 | yes |
Isnard | 2000 | 264 | 51±12 | 80 | cardiac mortality+urgent transplantation | 206 | 83 | 27±10 | 27 | yes |
Ghio | 2000 | 140 | 52±11 | 75 | cardiac mortality+urgent transplantation | 38 | 52 | 22±2 | 20 | yes |
McDonagh | 2001 | 1640 | 50,4±nr | 48 | overall mortality | 48 | 80 | 47±nr | 40 | no |
Neglia | 2002 | 64 | 52±12 | 87 | cardiac mortality | 82 | 24 | 34±10 | 35 | no |
Corrà | 2002 | 600 | 58±7 | 88 | cardiac mortality+urgent transplantation | 102 | 87 | 26±4 | 25 | yes |
Szachniewicz | 2003 | 176 | 63±nr | 86 | overall mortality | 18 | 32 | 42±nr | 35 | yes |
Gardner | 2003 | 142 | 50±10 | 82 | cardiac mortality+urgent transplantation | 55 | 24 | 14.9±7 | 13 | no |
Martinez-Selles | 2003 | 1065 | 75±nr | 49 | overall mortality | 51 | 507 | 35±7 | 30 | no |
Shiba | 2004 | 684 | 67±13 | 66 | overall mortality | 33 | 175 | 49±15 | 25 | no |
Guazzi | 2005 | 128 | 60±9 | 79 | cardiac mortality | 51 | 24 | 34±10 | 35 | yes |
Kistorp | 2005 | 195 | 69±nr | 71 | overall mortality | 30 | 46 | 30±8 | 25 | yes |
Junger | 2005 | 209 | 54±10 | 86 | overall mortality | 35 | 45 | 22±10 | 20 | yes |
Peterson | 2005 | 61 | 53±11 | 86 | overall mortality+urgent transplantation | 139 | 32 | 26±9 | 27 | no |
Bloomfield | 2006 | 549 | 56±10 | 71 | cardiac mortality | 24 | 51 | 25±6 | 31 | no |
Rossi | 2007 | 273 | 62±nr | 87 | overall mortality | 45 | 44 | 31±3 | 30 | yes |
Arslan | 2007 | 43 | 62±10 | 86 | overall mortality | 24 | 16 | 35±6 | 30 | yes |
Guazzi | 2007 | 288 | 55±13 | 62 | overall mortality | 33 | 62 | 33±13 | 28 | yes |
vonHaeling | 2007 | 525 | 61±12 | 94 | overall mortality | 28 | 171 | 28±4 | 20 | yes |
Nishio | 2007 | 145 | 67±1.8 | 70 | cardiac mortality+hospitalization | 33 | 28 | 31±nr | 30 | no |
Dini | 2007 | 356 | 70±6 | 22 | cardiac death | 34 | 54 | 31±3 | 25 | no |
Whalley | 2008 | 228 | 70±3 | 66 | cardiac mortality+hospitalization | 18 | 26 | 57±12 | 45 | no |
Dini | 2008 | 142 | 71±11 | 78 | overall mortality | 50 | 85 | 28±7 | 25 | no |
Parissis | 2009 | 300 | 65±11 | 83 | cardiac mortality+hospitalization | 12 | 92 | 28±4 | 25 | no |
Smilde | 2009 | 90 | 60±8 | 85 | overall mortality | 156 | 47 | 29±9 | 30 | yes |
EF = left ventricular ejection fraction; nr = not reported.