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. 2014 Jan 27;9(1):e85879. doi: 10.1371/journal.pone.0085879

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© 2014 David et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A) Illustration of the successive steps of a 4C-seq analysis. From top to bottom: coverage profile (reads density) is smoothed by a moving average. The smoothed density is corrected by fitting a model of the local interaction profile and long-range interacting regions are identified with the domainogram algorithm. B) From top to bottom: smoothed 4C-seq profiles for Hoxd13 and Hoxd4 in AT; the ChIP-seq density profiles of H3K27me3 and H3K4me3 in the same tissues with the peaks of H3K4me3 found by MACS. This figure was generated with the GDV genome viewer.