Table 2. Enhanced lignan uptake rate mediated by glycoprotein SC-2.
Incubation time, (min) | Schisandrin B | Schisandrin B+SC-2a | ||
Uptake (µM) | Decay rate constant, k1(min−1) | Uptake (µM) | Decay rate constant, k2 (L•mmol−1 min−1) | |
0 | 47b | - | 46b | - |
5 | 54±2 | 0.0140b | 58±2 | 2.016×10−5 b |
15 | 68±3 | 0.0140 | 82±2** | 2.016×10−5 |
30 | 76±3 | 0.0053 | 86±4* | 2.269×10−6 |
60 | 82±3 | 0.0020 | 91±5 | 1.429×10−6 |
90b | 86b | 0.0013b | 93b | 5.865×10−7 b |
120b | 82b | −00013b | 89b | −1.092×10−6 b |
Dose of SC-2 (MW: 841 kDa): 1 mg/mL ( = 1.1891×10−3 mM) (* p<0.05; ** p<0.01).
Values obtained by extrapolation.