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. 2014 Jan 27;9(1):e86215. doi: 10.1371/journal.pone.0086215

Table 6. Causes of DRPs in patients with BPH (n = 295).

Code Causes Number of causes (Percentage, %)
C1 Drug/Dose selection 248 (84.1)
C1.1 Inappropriate drug selection 128 (43.4)
C1.2 Inappropriate dosage selection 52 (17.6)
C1.4 Pharmacokinetic problems, including ageing/deterioration in organ function and interactions 1 (0.3)
C1.5 Synergistic/preventive drug required and not given 35 (11.9)
C1.7 New symptom or indication revealed/presented 4 (1.4)
C1.8 Manifest side effect, no other cause 28 (9.5)
C2 Drug use process 28 (9.5)
C2.1 Inappropriate timing of administration and/or dosing intervals 6 (2.0)
C2.2 Drug underused/under-administered 17 (5.8)
C2.3 Drug overused/over-administered 3 (1.0)
C2.5 Drug abused (unregulated overuse) 1 (0.3)
C2.6 Patient unable to use drug/form as directed 1 (0.3)
C3 Information 1 (0.3)
C3.1 Instruction for use/taking not known 1 (0.3)
C4 Patient/Psychological 9 (3.1)
C4.1 Patient forgets to use/take drug 2 (0.7)
C4.3 Patient suspects side effect 1 (0.3)
C4.5 Patient unwilling to bother physician 2 (0.7)
C4.7 Patient unwilling to adapt life-style 2 (0.7)
C4.8 Burden of therapy 1 (0.3)
C4.10 Patient takes food that interacts with drugs 1 (0.3)
C5 Logistics 5 (1.7)
C5.2 Prescribing error (only in case of slip of the pen) 5 (1.7)
C6 Other 4 (1.4)
C6.2 No obvious cause 4 (1.4)

Note: Only causes with the frequency of more than one were included.