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. 2014 Jan 27;9(1):e86536. doi: 10.1371/journal.pone.0086536

Figure 4. Inhibition of MEK and PI3K in combination alters contraction of collagen gels and SMA deposition in the lungs.

Figure 4

(A) Primary fibroblasts from the lung cultures of CCSP/TGFα transgenic mice on Dox for 4 wks were platted in 3D collagen gels for 4 or 7 days with media, ARRY, PX866 or inhibitors combined. Images were taken to quantify the changes in the surface of 3D collagen gels (B) Representative photomicrographs of lung tissues for each treatment group (n = 4/group) demonstrate changes in SMA staining in the fibrotic lesions of the pleura (upper panel) and adventitia (lower panel).