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. 2014 Jan 27;9(1):e87031. doi: 10.1371/journal.pone.0087031

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© 2014 Sandulache et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A) ATC (U-HTH7) cellular reducing potential is maintained largely through glucose catabolism. B) ATC (U-HTH83) inhibition of glucose catabolism using 2-deoxyglucose (2-DG) increases intra-cellular ROS levels in a dose dependent fashion. C) ROS perturbations trigger changes in cellular reducing potential. D) Inhibition of glucose catabolism radiosensitizes ATC cells (U-HTH83) in a dose dependent manner. These effects are reversed by NAC. Data are presented as averages with error bars representing standard deviation. Each experiment was performed at least in duplicate. *indicates p-value <0.05 compared to corresponding control condition unless otherwise indicated. (CNT = control, DCFDA = 2′,7′-dichlorodihydrofluorescein diacetate).