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. 2014 Jan 27;9(1):e87513. doi: 10.1371/journal.pone.0087513

Figure 4. Ubiquilin-1 Overexpression increased survival but had no effect on motor function or loss of body weight.

Figure 4

(A) Kaplan-Meier survival curve showing a 20% increase in lifespan in double transgenic mice (R6/2: N = 14, R6/2-UBQ1: N = 7, p = 0.0032). (B–D) Ubiquilin-1 overexpression failed to improve rotarod performance (B), grip strength (C) and activity in the open field (D), at any time point tested. (E) There was no significant effect of ubiquilin-1 overexpression on weight loss. For all behavioral experiments: (WT: N = 4, UBQ1: N = 12, R6/2: N = 10, R6/2-UBQ1: N = 7).