Table 1. Applications of pig as humanized-graft resource.

Category	Proof-of-concept rodent model		Pig model
Whole animal (in vivo organogenesis)a	pancreas	Kobayashi T et al. Cell 20109	pancreas	Matsunari H et al. PNAS 201312
	liver	Hata T et al. Ann Surg 201310	liver	Fisher JE et al. Liver Transpl 201313
	kidney	Usui J et al. Am J Pathol 201211	SCID pig	Suzuki S et al. Cell Stem Cell 201214
Donor of embryonic primordiumb	kidney	Matsumoto K et al. Stem Cells 201215	pancreas	Hammerman M. Organogenesis 201216
Donor of decellularized organc	heart	Ott HC et al. Nat Med 200817
	kidney	Ross EA et al. JASN 200918	kidney	Orlando G et al. Ann Surg 201221
	liver	Uygun BE et al. Nat Med 201019	liver	Yagi H et al. Cell Transplant 201322
	lung	Ott HC et al. Nat Med 201020

^a By blastocyst complementation or injection of human stem cells or progenitor cells to generate human organs in a living pig. ^b Implantation of pig embryonic primordia with human stem cells to achieve human organogenesis in the patient. ^c Reconstruction of human organs in vitro by use of decellularized organ scaffold with human stem cells.