Table 1. IC50 values for cDDP and paclitaxel in NT2-D1 cells pretreated with retinoic acid.
cDDP IC50 µM | Fold increase in IC50 induced by pretreatment | P Value | Paclitaxel IC50 µM | Fold increase in IC50 induced by pretreatment | P Value | |
NT2-D1 No pretreatment | 0.23±0.01 | 1 | - | 0.0018±0.00001 | 1 | - |
NT2-D1 pretreated with 0.01 µM RA | 0.40±0.04 | 1.7 | <0.01 | 0.0018±0.00004 | 1 | NS |
NT2-D1 pretreated with 0.1 µM RA | 3.05±0.61 | 13.3 | <0.01 | 0.0026±0.00004 | 1.4 | <0.001 |
NT2-D1 pretreated with 10 µM RA | 4.28±0.28 | 18.6 | <0.001 | 0.11±0.01 | 61 | <0.01 |