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Surface representations of MCA2-6H corresponding to a molecular size of 200 kDa. (A) Top view, (B) bottom view, (C) side view, and (D) side view turned 45° in the z-axis, which is superposed with the crystal structure of the transmembrane segment of the M2 proton channel protein from influenza A virus (PDB #3C9J) and schematic illustration of the bilayer lipid membrane to propose membrane topology.
