Table 6.
Clinical outcomes and hospital resource use
| Outcome, n (%) | Early responders n = 332 | Later responders n = 253 | Patients without Halm-based assessment of TCS n = 1454 |
|---|---|---|---|
| Antibiotic treatment modification while on initial therapy (excluding streamlining*) |
47 (14.2) |
88 (34.8) |
454 (31.2) |
| Time to clinical stability, days, mean (SD) [median] |
2.6 (0.95) [3.0] |
9.0 (6.53) [7.0] |
5.7 (5.0) [5.0] |
| Length of stay†, days, mean (SD) [median] |
9.4 (7.0) [8.0] (n = 309) |
15.6 (10.5) [12.0] (n = 246) |
12.6 (10.7) [10.0] (n = 1423) |
| Length of stay after achievement of clinical stability‡, days, mean (SD) [median] |
5.9 (7.1) [4.0] (n = 305) |
5.9 (7.0) [3.0] (n = 231) |
N/A |
| Patients admitted to ICU |
11 (3.3) |
54 (21.3) |
213 (14.6) |
| Time in ICU‡, days, mean (SD) [median] (n) |
6.2 (5.7) [4.0] (n = 11) |
10.4 (10.1) [8.0] (n = 53) |
9.5 (12.4) [5.0] |
| Patients admitted to ICU after achievement of clinical stability |
0 |
1 (0.4) |
N/A |
| Reinfection/recurrence§ |
11 (3.3) |
15 (5.9) |
68 (4.7) |
| Home-based care after discharge |
6 (1.8) |
11 (4.3) |
56 (3.9) |
| Blood pressure support during hospitalization |
|
|
|
| Fluid resuscitation |
24 (7.2) |
37 (14.6) |
190 (13.1) |
| Vasopressors |
2 (0.6) |
17 (6.7) |
82 (5.6) |
| Invasive procedures |
1 (0.3) |
3 (1.2) |
26 (1.8) |
| Isolation required |
28 (8.4) |
24 (9.5) |
102 (7.0) |
| Mechanical ventilation required during hospitalization |
24 (7.2) |
48 (19.0) |
208 (14.3) |
| Invasive |
12 (3.6) |
28 (11.1) |
99 (6.8) |
| Non-invasive |
12 (3.6) |
25 (9.9) |
129 (8.9) |
| Parenteral nutrition |
5 (1.5) |
19 (7.5) |
70 (4.8) |
| Duration of parenteral nutrition, days, mean (SD) [median] |
6.0 (3.5) [5.0] (n = 5) |
8.2 (5.1) [6.5] (n = 18) |
9.5 (12.0) [5.0] (n = 65) |
| Acute renal failure necessitating renal replacement therapy |
1 (0.3) |
6 (2.4) |
39 (2.7) |
| Duration of renal failure, days, mean (SD) [median] |
2.0 (0) [2.0] (n = 1) |
14.3 (16.0) [9.5] (n = 4) |
5.7 (7.2) [3.0] (n = 32) |
| Septic shock during hospitalization |
1 (0.3) |
20 (7.9) |
63 (4.3) |
| Mortality |
2 (0.6) |
4 (1.6) |
141 (9.7) |
| Post-discharge mortality | 0 | 0 | 0 |
*De-escalation of treatment to narrower-spectrum antibiotics upon patient improvement or confirmed microbiological diagnosis.
†Includes duration of all hospitalizations for patients with recurrences.
‡Does not include duration of all hospitalizations for patients with recurrences.
§Refers to patients hospitalized again (due to CAP) after initial discharge.
ICU = intensive care unit; N/A = not applicable; SD = standard deviation.