Table 1. ITC Analysis of PMC-5, PMC-6, PMC-7, and PMC-567 Binding to Papain.
pH Level | Kd (μM) | ΔH (kcal*mol−1) | ΔS (cal*mol−1*deg−1) |
---|---|---|---|
pH 5.2 | |||
PMC-5 | 8.1 ± 2.8 | −2.83 ± 0.06 | −19.8 |
PMC-6 | 9.0 ± 2.3 | −2.95 ± 0.1 | −17.8 |
PMC-7 | 8.9 ± 1.8 | −2.75 ± 0.2 | −18.5 |
PMC-567 | 14 ± 3.4 | −3.47 ± 0.4 | −15.4 |
PMC-6 truncated | NBa | NBa | NBa |
pH 7.2 | |||
PMC-5 | 7.2 ± 3.1 | −2.78 ± 0.06 | −18.8 |
PMC-6 | 9.4 ± 4.2 | −2.90 ± 0.1 | −17.9 |
PMC-7 | 9.8 ± 3.2 | −2.54 ± 0.1 | −20.4 |
PMC-567 | NB* | NB* | NB* |
No binding.