Table 6.
Adverse events
| Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 | |
|---|---|---|---|---|---|
|
Hypercalcemia |
2* |
|
|
|
|
|
Hypomagnesemia |
1 |
|
|
|
|
|
Hypercholesterolemia |
6 |
|
|
|
|
|
Hyperchloremia |
1 |
|
|
|
|
|
Increased liver enzymes |
5 |
2 |
1 |
|
|
|
Hypokalemia |
3 |
|
|
|
|
|
Hyponatremia |
3 |
|
|
|
|
|
Hypochloremia |
3 |
|
|
|
|
|
Neutropenia |
|
2 |
1 |
1** |
|
|
Increased creatinine |
|
1 |
|
|
|
|
Increased BUN |
1 |
|
|
|
|
|
Hypophosphatemia |
1 |
|
|
|
|
|
Lethargy |
1 |
|
|
|
|
|
Anorexia |
1 |
|
|
|
|
|
Diarrhea |
1 |
|
|
|
|
|
Pulmonary |
|
|
|
|
2 |
| Dermatopathy | 2 | 4 |
*Associated with disease progression in 1 patient.
**Neutropenia existed prior to treatment in this patient.