Table 2.

IFN-γ, Foxp3, and IL-17 mRNA relative expression in PB CD4+ T cells of RA patients and normal controls; the median levels of mRNA [interquartile range]

	IFN mRNA	Foxp3 mRNA	IL-17 mRNA
MTX group
Before therapy	1.81 [1.53–3.21]	0.004 [0.002–0.006]	0.027 [0.014–0.048]
After therapy	1.59 [1.34–2.67]	0.003 [0.001–0.004]	0.016* [0.011–0.036]
iTNF group
Before therapy	1.5 [0.55–2.17]	0.003 [0.001–0.004]	0.021** [0.07–0.034]
After therapy	1.53 [0.71–2.5]	0.003 [0.001–0.005]	0.036 [0.018–0.052]
Control group	1.4 [0.76–1.73]	0.001 [0.001–0.002]	0.017*** [0.011–0.018]

* P = 0.048, ** P = 0.007, *** P = 0.01  compared to the iTNF group after therapy