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c-Fos protein expression in rat prefrontal cortex with and without restraint stress. In the absence of stress, LSN2424100 (n = 7) had no effect on c-fos levels compared to vehicle treated subjects (p > 0.05; n = 7). Restraint stress significantly increased c-fos levels in vehicle-treated rats (***p < 0.001; n = 7), and this effect was blocked by both LSN2424100 (†††p < 0.001; n = 6) and alprazolam (†p < 0.05; n = 6).
