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. 2014 Jan 28;8:5. doi: 10.3389/fnins.2014.00005

Figure 3.

Figure 3

Antidepressant-like effect of imipramine on DRL-72-s responding in rats and DRL-36-s responding in mice. Consistent with literature reports, imipramine produced a significant antidepressant-like effect in both rat DRL-72-s (A; n = 12) and mouse DRL-36-s models (B; n = 16), as demonstrated by a significant increase in reinforcers (p < 0.001 and p < 0.01, respectively) and significant decrease in total responses emitted (p < 0.01 and p < 0.001, respectively). Importantly, the antidepressant-like efficacy of imipramine was not altered in mice lacking OX1 or OX2 receptors (C,D, respectively; n = 8). *p < 0.05 vs. respective vehicle, Dunnett's post-hoc analyses.