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. 2014 Jan 28;8:5. doi: 10.3389/fnins.2014.00005

Figure 4.

Figure 4

SB334867 failed to produce antidepressant-like effects in rat DRL-72-s or mouse DRL-36-s. (A) SB334867 did not affect total responses or reinforcers received in male SD rats maintained on a DRL-72-s schedule of responding within a dose range of 3–30 mg/kg (n = 7). Importantly, the positive control, imipramine, did produce an antidepressant-like effect in this experiment at 10 mg/kg; (B) no significant effect of SB334867 was observed on total responses emitted or reinforcers received in C57Bl/6 mice (n = 7); (C) significant decrease in total responses emitted by mice lacking OX1 receptors at 20 and 40 mg/kg (p < 0.01), with a concomitant increase in reinforcers received at 20 mg/kg (p < 0.01; n = 8); (D) significant decrease in total responses emitted (p < 0.05) without a concomitant increase in reinforcers received, by mice lacking OX2 receptors, at 40 mg/kg (n = 8). *p < 0.05 vs. respective vehicle, Dunnett's post-hoc analyses.