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. 2014 Jan 28;8:5. doi: 10.3389/fnins.2014.00005

Figure 6.

Figure 6

Antidepressant-like effects of LSN2424100 on DRL-72-s responding in rats and DRL-36-s responding in mice. (A) dose-dependent increase in the number of reinforcers obtained by male SD rats in DRL-72-s (n = 7), with a significant effect at 30 mg/kg (p < 0.05) and a significant decrease in total responses emitted at 10 and 30 mg/kg (p < 0.05); (B) a significant decrease in total responses emitted by C57Bl/6 mice in DRL-36-s at 10 mg/kg (p < 0.05; n = 8); (C) antidepressant-like efficacy of LSN2424100 is maintained in mice lacking OX1 receptors, with a significant increase in reinforcers obtained and a significant decrease in responses at 20 mg/kg (p < 0.05; n = 8); (D) antidepressant-like effect of LSN2424100 is lost in mice lacking OX2 receptors, as illustrated by lack of significant effects in either responses emitted or reinforcers received at all doses (n = 8). *p < 0.05 vs. respective vehicle, Dunnett's post-hoc analyses.