Table 2.
Pharmacokinetic datafor LY2424100a.
| Parameterb | 30 mg/kg IP | 30 mg/kg PO |
|---|---|---|
| AUC0–6 h (ng*h/ml) | 1300 | 269 |
| Cmax (ng/ml) | 1170 | 196 |
| tmax (hr) | 0.5 | 0.5 |
| Brain concentrationc (ng/g) | 77.2 | 33.5 |
| Plasma concentrationc (ng/ml) | 149 | 45.8 |
| Brain:plasma ratioc | 0.52 | 0.72 |
| Fu (brain/plasma) | 0.0089/0.0341 | |
| Ccu (brain/plasma, nM) | 5.93/2.99 | 0.67/3.52 |
a
n = 2 cannulated rats/dose.
b
Abbreviations: AUC0–6 h, area under the concentration vs. time curve from time 0–6 h; Cmax, maximum observed drug concentration; tmax, time to maximum observed drug concentration; Fu, fraction unbound in brain/plasma; Cu (unbound or free concentration) = Ctotal × Fu.
c
Two hours post treatment.