Table 4.

Association of individual components of dialysis dose with IDH

	Odds Ratio for IDH (95%CI)
	Unadjusted	Model 1	Model 2
Session Length (mins)
≤180 (ref)	1.00	1.00	-
181–209	1.06 (0.93–1.21)	1.15 (1.01–1.33)	-
210–239	1.00 (0.87–1.15)	1.08 (0.94–1.24)	-
≥240	0.85 (0.73–1.00)	0.95 (0.80–1.12)	-
	Unadjusted	Model 1
Qb (mL/min)
≤250 (ref)	1.00	1.00	-
251–350	0.84 (0.75–0.95)	0.89 (0.78–1.01)	-
351–450	0.77 (0.68–0.88)	0.87 (0.75–0.99)	-
>450	0.61 (0.49–0.76)	0.71 (0.56–0.90)	-
	Unadjusted	Model 1
Qd (mL/min)
≤500 (ref)	1.00	1.00	-
501–799	0.56 (0.49–0.64)	0.58 (0.50–0.66)	-
≥800	0.98 (0.88–1.09)	0.98 (0.88–1.09)	-
	Unadjusted	Model 1	Model 2a
KoAurea (mL/min)
<1000 (ref)	1.00	1.00	1.00
>=1000	0.98 (0.89–1.08)	1.05 (0.95–1.16)	1.15 (1.04–1.27)
	Unadjusted	Model 1	Model 2b
Rate of decline in plasma BUN (mg/dL/hour)	1.04 (1.03–1.06)	1.05 (1.04–1.06)	1.05 (1.04–1.06)

Associations of exposures of interest with intra-dialytic hypotension are presented as odds ratios (95% confidence intervals). Estimates were calculated using generalized linear models. Model 1 presents the effect estimates for each exposure of interest after adjustment for HEMO study flux assignment (higher vs lower), age, race (black, non-black), sex, post-dialysis weight, sex-by-weight cross-product terms, access, pre-dialysis SBP, height, ischemic heart disease, congestive heart failure (none, mild, moderate/severe), peripheral vascular disease, diabetes mellitus, arrhythmia, serum sodium, creatinine, albumin, phosphorus, bicarbonate and ultrafiltration requirement. Model 2a adjusts for the same covariates in Model 1, in addition to Qb, Qd and session length. Model 2b adjusts for the same covariates as Model 1, in addition to Qb and Qd.

Qb, blood flow; Qd, dialysate flow; KoA_urea, dialyzer mass transfer coefficient for urea.