. Author manuscript; available in PMC: 2014 Jan 28.

Published in final edited form as: Future Microbiol. 2013 Nov;8(11):1475–1487. doi: 10.2217/fmb.13.109

Table 1. Compounds targeting host factors required for norovirus replication.

Compound	Cellular target	Inhibitory activity
FE15 and derivatives	DDX3	Inhibits ATPase activity of DDX3. Not tested against noroviruses, but antiviral activity proven for HIV
Hippuristanol	eIF4A	Inhibits activity of eIF4A and potently inhibits MNV in cell culture
WP1130	USP14	Inhibits virus replication in vivo
HBSC compounds	La protein	Not tested against noroviruses, but antiviral activity shown for HBV
Camptothecine and derivatives	hnRNP A1	Not tested against noroviruses

MNV: Murine norovirus.