Table 1. Compounds targeting host factors required for norovirus replication.
Compound | Cellular target | Inhibitory activity |
---|---|---|
FE15 and derivatives | DDX3 | Inhibits ATPase activity of DDX3. Not tested against noroviruses, but antiviral activity proven for HIV |
Hippuristanol | eIF4A | Inhibits activity of eIF4A and potently inhibits MNV in cell culture |
WP1130 | USP14 | Inhibits virus replication in vivo |
HBSC compounds | La protein | Not tested against noroviruses, but antiviral activity shown for HBV |
Camptothecine and derivatives | hnRNP A1 | Not tested against noroviruses |
MNV: Murine norovirus.