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. Author manuscript; available in PMC: 2014 Jan 28.
Published in final edited form as: Clin Immunol. 2012 Dec 20;146(3):197–206. doi: 10.1016/j.clim.2012.12.002

Figure 4. Interactions between DCs and aPL Abs may be enhanced by glycation and oxidation of aPL Abs.

Figure 4

In atherosclerosis, diabetes and aging, the microenvironment predisposes local β2GPI to glycation and/or oxidation, initiating a local autoimmune process leading to inflammation, endothelial dysfunction and accelerated atherosclerosis.