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. 2014 Jan 9;141(2):211–221. doi: 10.1111/imm.12181

Figure 4.

Figure 4

Chemokine expression is up-regulated in the serum and colon tissue of tumour necrosis factor-related apoptosis-inducing ligand receptor deficient (TRAIL-R−/−) mice. Wild-type (WT) (n = 6) and TRAIL-R−/− (n = 6) mice were fed 2·5% dextran sulphate sodium (DSS) for 5 days. Secreted chemokines in the serum were measured by ELISA. (a) CCL2/MCP-1 production in the serum; P = 0·034. (b) CXCL1/KC production in the serum; P = 0·003. (c) and (d) Colon tissues (200 ± 5 mg) from WT and TRAIL-R−/− mice were cut into small pieces and cultivated in serum-free RPMI-1640 medium for 24 hr. CCL2/MCP-1 (c, P = 0·015) and CXCL1/KC (d, P = 0·871) production in the colon tissue cultures was detected by ELISA.