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. 2013 Dec 23;171(2):498–508. doi: 10.1111/bph.12482

Figure 1.

Figure 1

Hepatomegaly and severe steatohepatitis in EC-AMPK mice fed with high-fat diet. After 16 weeks of high fat diet, liver tissues were collected from wild-type and EC-AMPK mice for measuring the wet weights and triglyceride contents (A), and histological analysis after haematoxylin and eosin staining (B). Magnification: 100× and 400×. Serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were quantified by commercial assay kits (C). The mRNA expression of inflammatory markers F4/80 and CD68 was evaluated by quantitative RT-PCR analysis and calculated as percentage changes against samples derived from wild-type mice (D). *P < 0.05 versus wild type mice group, n = 5–8.