TABLE 3.
Final Model and Bootstrap PK Parameters
| Parameter | Point estimate |
%RSE | Bootstrap confidence interval |
||
|---|---|---|---|---|---|
| 2.5% | Median | 97.5% | |||
| CL (L/h/kg) | 0.305 | 13.9 | 0.237 | 0.307 | 0.379 |
| V (L/kg) | 2.80 | 14.8 | 1.82 | 2.80 | 3.67 |
| CL, PMA | 3.02 | 11.5 | 2.39 | 3.02 | 4.18 |
| Inter-individual variability (CV%) | |||||
| CL | 52.8 | 36.2 | 35.6 | 53.2 | 84.4 |
| V | 85.0 | 51.5 | 4.89 | 81.3 | 140 |
| CL vs. V correlation coefficient | 0.98 | 45.7 | 0.62 | 1.00 | 1.02 |
| Proportional residual variability (CV%) | 34.5 | 35.0 | 21.1 | 32.0 | 43.4 |
CV%, coefficient of variance; RSE, relative standard error.