Table 3.

Comparison of four designs for scenario 3 (bold-faced numbers correspond to the true MTD)

Dose	True toxicity probability	Design
		A	B	C	D	E
Recommended dose level (%)
0	-	38	-	-	-	-
1	0.22	37	52	61	54	61
2	0.32	20	35	26	30	28
3	0.45	5	10	14	14	11
4	0.54	0	2	0	2	0
5	0.69	0	0	0	0	0
6	0.80	0	0	0	0	0
Dose level treated at (%)
1	0.22	63	17	68	51	55
2	0.32	27	13	23	23	26
3	0.45	9	13	5	15	14
4	0.54	2	13	3	7	4
5	0.69	0	14	1	3	1
6	0.80	0	31	0	1	0
Median DLT rate (min, max)		33 (13, 100)	54 (17, 95)	30 (8, 60)	33 (9, 90)	30 (13, 90)
Median trial length, months (min, max)		25 (5, 63)	13 (18, 20)	18 (13, 44)	29 (16, 52)	101 (61, 156)
Median number of patients (min, max)		12 (3, 27)	24 (11, 24)	10 (10, 24)	14 (10, 24)	16 (10, 24)