Table 4.
Comparison of four designs for scenario 4 (bold-faced numbers correspond to the true MTD)
| Dose | True toxicity probability | Design |
||||
|---|---|---|---|---|---|---|
| A | B | C | D | E | ||
| Recommended dose level (%) | ||||||
| 0 | - | 56 | - | - | - | - |
| 1 | 0.30 | 33 | 78 | 82 | 79 | 83 |
| 2 | 0.40 | 10 | 19 | 14 | 17 | 14 |
| 3 | 0.52 | 1 | 3 | 4 | 4 | 3 |
| 4 | 0.61 | 0 | 0 | 0 | 0 | 0 |
| 5 | 0.76 | 0 | 0 | 0 | 0 | 0 |
| 6 | 0.87 | 0 | 0 | 0 | 0 | 0 |
| Dose level treated at (%) | ||||||
| 1 | 0.30 | 75 | 22 | 79 | 63 | 71 |
| 2 | 0.40 | 20 | 13 | 17 | 19 | 18 |
| 3 | 0.52 | 4 | 12 | 3 | 12 | 8 |
| 4 | 0.61 | 1 | 12 | 1 | 4 | 2 |
| 5 | 0.76 | 0 | 13 | 0 | 1 | 1 |
| 6 | 0.87 | 0 | 29 | 0 | 0 | 0 |
| Median DLT rate (min, max) | 33 (13, 100) | 58 (21, 95) | 31 (8, 80) | 38 (9, 83) | 36 (15, 82) | |
| Median trial length, months (min, max) | 16 (5, 55) | 13 (9, 20) | 16 (13, 40) | 26 (16, 52) | 76 (61, 156) | |
| Median number of patients (min, max) | 6 (3, 24) | 24 (10, 24) | 10 (10, 24) | 12 (10, 24) | 12 (10, 24) | |