Table 7.
Impact of design parameters (m, c) on Design D based on scenario 1, i.e. true toxicity probabilities (0.05, 0.1, 0.25, 0.35, 0.5, 0.7). The first number represents the mean and the second the standard deviation (in parenthesis).
| trial length | % with DLT | % treated above MTD | patient number | % select true MTD | |
|---|---|---|---|---|---|
| Design D | |||||
| m=2, c=5 | 23.2 (3.4) | 30.9 (12.6) | 47.6 (33.0) | 18.7 (3.9) | 43.9 |
| m=2, c=10 | 26.5 (3.7) | 30.0 (11.2) | 45.3 (32.4) | 18.6 (3.5) | 44.2 |
| m=2, c=15 | 29.3 (4.2) | 29.4 (10.2) | 43.7 (31.8) | 18.6 (3.2) | 43.7 |
| m=2, c=20 | 31.8 (4.6) | 29.2 (9.2) | 43.1 (31.1) | 18.8 (3.1) | 43.6 |
| m=2, c=25 | 34.1 (4.9) | 28.8 (8.8) | 42.1 (30.5) | 19.2 (3.0) | 44.2 |
| m=4, c=5 | 31.0 (6.1) | 28.4 (12.5) | 42.5 (34.5) | 17.9 (4.3) | 45.8 |
| m=4, c=10 | 36.3 (6.5) | 27.9 (10.8) | 40.5 (33.6) | 17.4 (3.6) | 44.8 |
| m=4, c=15 | 40.7 (7.3) | 27.4 (9.8) | 38.3 (32.8) | 17.3 (3.3) | 43.4 |
| m=4, c=20 | 44.9 (8.0) | 27.1 (9.2) | 38.1 (32.4) | 17.6 (3.2) | 43.9 |
| m=4, c=25 | 49.2 (8.5) | 27.1 (8.5) | 38.0 (31.9) | 17.9 (3.1) | 44.8 |
| m=6, c=5 | 37.2 (9.2) | 26.6 (12.3) | 38.5 (36.4) | 16.1 (4.1) | 46.4 |
| m=6, c=10 | 44.8 (10.2) | 26.3 (10.4) | 36.9 (33.7) | 16.9 (3.9) | 47.0 |
| m=6, c=15 | 50.9 (11.2) | 26.1 (9.7) | 35.9 (33.4) | 16.8 (3.4) | 46.6 |
| m=6, c=20 | 56.6 (11.9) | 25.8 (8.9) | 35.2 (33.4) | 16.9 (3.1) | 44.7 |
| m=6, c=25 | 62.0 (12.8) | 25.5 (8.4) | 34.0 (32.7) | 17.1 (3.1) | 45.3 |
| Design A: 3+3 | 36.4 (10.3) | 20.2 (6.6) | 18.1 (20.2) | 16.5 (4.4) | 29.0 |
| Design B: TITE-CRM | 12.9 (2.0) | 46.2 (11.0) | 72.8 (16.1) | 20.8 (3.2) | 40.9 |
| Design E: CRM | 122.5 (18.8) | 25.3 (6.2) | 33.3 (30.3) | 19.3 (2.9) | 47.3 |