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. Author manuscript; available in PMC: 2014 Jan 28.

Published in final edited form as: Nat Rev Drug Discov. 2010 Oct;9(10):775–789. doi: 10.1038/nrd3179

In thiscartoon we graphically represent the relationship between critical oncogenic transcriptome networks and the miRNome. Target mRNAs for each major pathway are represented by circles with a unique color. MiRNAs are represented as hairpins structures in the center. The arrows connecting miRNAs and mRNAs indicate validated mRNA-miRNA interactions. The small arrow next to the circles indicate the biological effects on the pathway by the miRNA action on its target (i.e. miR-15a induces apoptosis by targeting BCL-2 or miR-29b suppresses cell proliferation by blocking CDK6. Some miRNAs like miR-29b, coordinately regulate multiple targets within different pathways. As shown in the cartoon, miR-29b modulates target mRNAs involved in apoptosis, cell proliferation, DNA methylation, histone acetylation and cell adhesion.

In thiscartoon we graphically represent the relationship between critical oncogenic transcriptome networks and the miRNome. Target mRNAs for each major pathway are represented by circles with a unique color. MiRNAs are represented as hairpins structures in the center. The arrows connecting miRNAs and mRNAs indicate validated mRNA-miRNA interactions. The small arrow next to the circles indicate the biological effects on the pathway by the miRNA action on its target (i.e. miR-15a induces apoptosis by targeting BCL-2 or miR-29b suppresses cell proliferation by blocking CDK6. Some miRNAs like miR-29b, coordinately regulate multiple targets within different pathways. As shown in the cartoon, miR-29b modulates target mRNAs involved in apoptosis, cell proliferation, DNA methylation, histone acetylation and cell adhesion.