Table 4.
Re-irradiation for cerebral metastases: overview of publications
| Shehata et al. [10] | Kurup et al. [11] | Hazuka and Kinzie [12] | Cooper et al. [13] | Wong et al. [14] | Abdel-Wahab et al. [15] | Sadikov et al. [16] | Son et al. [9] | Present study | |
|---|---|---|---|---|---|---|---|---|---|
| n |
35 |
56 |
44 |
52 |
86 |
15 |
72 |
17 |
134 |
| Initial RT |
1×10 Gy, |
3×6 Gy |
10×3 Gy |
10×3 Gy |
10×3 Gy |
15×2 Gy |
5×4 Gy |
14×2.5 Gy |
15×2 Gy |
| 10×3 Gy | |||||||||
| Re-RT |
1×10 Gy |
10×2 Gy |
8×3.125 Gy |
10×2.5 Gy |
10×2 Gy |
20×1.5 Gy twice daily (partial brain) |
10×2.5 Gy |
12×1.8 Gy |
10×2 Gy |
| Interval |
- |
6.3 mo (mean) |
7.8 mo (median) |
> 4 mo |
7.6 mo (median) |
10 mo (median) |
9.6 mo (median) |
15 mo (median) |
13.4 mo (median) |
| Response |
|
|
|
|
|
|
|
|
|
| Improve |
68% |
75% |
27% |
42% |
70% |
60% |
40% |
80% |
39% |
| Stable |
25% |
12.5% |
41% |
52% |
29% |
27% |
33% |
20% stable or no response |
44% |
| None |
|
12.5% |
14% |
6% |
|
|
33% |
|
17% |
| Toxicity |
17% acute side effects |
18% acute side effects 1 radiation necrosis |
8 autopsies, 3 brain necroses |
- |
5 patients with radiographic abnormality |
|
1 patient with severe side effects 3 unable to complete RT |
71% with acute side effects |
67% with acute side effects 10% unable to complete RT |
| Survival after re-irradiation | - | 3.5 mo median | 2 mo median | 4 mo median | 4 mo median | 3.2 mo median | 4.1 mo median | 5.2 mo median | 2.8 mo median |