. 2013 Jun 11;4(8):710–714. doi: 10.1021/ml4000904

Table 1. Stability and Direct Cytotoxicity of Novel Generation of Pyridinols^a.

N	microsomal stability % left	cellular toxicity (EC₅₀, μM ± SEM)
ApAP	65 ± 12	594 ± 147
12	108 ± 12	4760 ± 36
13	87 ± 7	2965 ± 284
14	97 ± 3	>5000

Microsomal stability is expressed as % of unmodified compound remaining after reaction. Microsomal stability values represent means ± SD. Cellular toxicity is expressed as the concentration causing a 50% decrease in total cellular ATP levels in HepG2 cells. Cellular toxicity values represent means ± SEM.

Table 1. Stability and Direct Cytotoxicity of Novel Generation of Pyridinolsa.

Table 1. Stability and Direct Cytotoxicity of Novel Generation of Pyridinols^a.