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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Breast Cancer Res Treat. 2013 Nov 12;142(3):489–503. doi: 10.1007/s10549-013-2741-5

Figure 1. Obesity-mediated decrease in latency correlates with elevated HGF expression.

Figure 1

A) Upon initiation of 10, 45 and 60% kcal derived from fat diets at 10 weeks of age, mice were palpated three times weekly for tumor onset. Hazard ratios comparing either 45% or 60% to 10% were 2.41 or 2.87, respectively. Median latencies are indicated ((10% vs. 45% p=0.0236 and 10% vs. 60% p=0.0091). B) Number of tumors was detected at sacrifice (n=15 mice). C) Tumor volume was measured by ultrasound (n=15 mice). D) HGF mRNA expression was determined using qPCR analysis in n=8 normal mammary glands. * 10% vs. 60% (P = 0.025).