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Dose-response analysis of a TMEM16A inhibitor (TMinh-A01) measured in TMEM16A-expressing FRT cells. A. The microfluidic chamber was perfused for 10 min with PBS containing 0 or 30 μM TMinh-A01. Time course of cellular fluorescence in different rectangular areas corresponding to indicated TMinh-A01 concentrations. Inset shows dose-response analysis done by platereader assay. B. Deduced single-shot dose-response with fitted IC50 of 0.35 μM and nH of 2.2.
